radiation, hypokinesia, food supplementation) could be a reason for many pathological states since they destroyed the evolution-determined existing balance of major and trace elements in the human body. Furthermore, it was shown that anthropogenic alterations of the internal milieu, as well as external influence (e.g. These specific changes can be successfully used to aid diagnoses. It was found that the elemental content of tissues and fluids changes greatly with different diseases. The results of the study confirmed well the hypothesis of elemental homeostasis. Also studied was the age variation of chemical element content in intact human tissues and fluids (bone, teeth, thyroid, prostate, mammary gland, intestine, lung, rectum, hair, whole blood, blood plasma and serum, mixed saliva and prostatic tissue and secretion). Neutron activation and X-ray fluorescence methods for the assessment of about 25 of the most important major and trace elements have been developed under clinical conditions for material obtained from both in vivo and in vitro (the material obtained from puncture biopsies, smears, scrapings, etc., in addition to either resected or necropsied material) application. Further the considerable development of methods used in nuclear physics and semiconductor engineering in the fifties and sixties opened new wide-scale prospects for study of the elemental composition of the human body. Knowledge that the elemental homeostasis under normal conditions can be changed under both pathological states and unfavorable action of the environment, can provide a powerful method of investigation. This tool studies the content of chemical elements in human tissues and fluids and this choice of a research field was based on the following hypothesis.
Following new developments in analytical techniques, an attempt to develop them further as a new medical tool (to be employed with available medical tools such as those using anatomic, physiological, morphological, biochemical, methods etc.) was made.
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